Demisone 0.5mg Tablets

Characteristics of Demisone 0.5mg

Demisone is a steroid drug with anti-inflammatory and immunosuppressive properties. It is also used to improve dermatological diseases such as atopic dermatitis and allergic diseases such as bronchial asthma. Currently, the active ingredient, dexamethasone, is approved in USA as a therapeutic agent for new coronavirus infections.

High anti-inflammatory and immunosuppressive effects, effective in various immune system diseases

• Widely used for allergies and immune system diseases
• One of the most powerful steroids
• It is equivalent to the new coronavirus (COVID-19) drug approved in USA

Effect/Efficacy

Improvement of allergic diseases, autoimmune diseases, arthritis, asthma, etc.

Demisone is a corticosteroid with immunomodulatory/suppressive and anti-inflammatory effects.

The immune system originally works to eliminate harmful substances and foreign substances that invade the body. However, sometimes the immune system malfunctions and attacks the body’s own normal tissues as foreign substances.

When this happens, immune attacks cause inflammation and tissue damage, resulting in various types of disorders. Typical examples are collagen diseases such as rheumatism, asthma, and abnormal thyroid function.

A definitive cure for these immune disorders has yet to be found, and treatment is done by suppressing the immune response with medication.

Demisone’s active ingredient, dexamethasone, is one of the synthetic adrenocortical hormones called corticosteroids that act in the same way as glucocorticoids. Glucocorticoids are naturally occurring hormones in the body that suppress the immune system and prevent excessive inflammatory reactions.

Dexamethasone is more potent and longer acting than glucocorticoids and is used for a variety of immune system disorders.

About Demisone 0.5mg

Demisone is a synthetic corticosteroid (steroid) agent. The active ingredient, dexamethasone, blocks the action of hormones called glucocorticoids produced in the adrenal cortex. It has anti-inflammatory and immunosuppressive effects and is used to treat diseases caused by abnormal immune function.

There are many types of diseases that are caused by abnormalities in immune function.

Much is still unknown about the causes of immune system disorders, and there is no silver bullet. Corticosteroids such as Demisone also cannot cure the disease itself. However, corticosteroids are used for treatment because they are effective in relieving the symptoms of immune system diseases and improving life prognosis.

Prior to the 1950s, systemic lupus erythematosus, known as a typical collagen disease, had a 5-year survival rate of less than 30%. The annual survival rate is up to 95%. In addition to the survival rate, patients’ QOL has improved dramatically due to improvements in pain caused by inflammation.

New coronavirus (COVID-19) approved for treatment of critically ill patients

In May 2020, a dexamethasone preparation equivalent to Demisone was approved as a treatment for the novel coronavirus (COVID-19) in USA. However, it is applied as an immunomodulator, not as an antiviral drug.

The human body contains proteins called cytokines that are secreted in response to viruses and bacteria. Cytokines protect the body through three functions: gathering immune cells at sites invaded by viruses and bacteria, differentiating immune cells into cells suitable for attack by invading viruses and bacteria, and activating immune cells.

Cytokines, which are normally produced in the amount necessary to fight viruses, become uncontrollable under the influence of an infectious disease, resulting in a large number of cytokines that cause fatal damage to the body. runaway).

Cytokine storms cause acute respiratory distress syndrome and multiple organ failure. It is thought that this cytokine storm is also occurring in patients who are infected with the new coronavirus and become severe. This is because the new coronavirus increases the production of the inflammatory cytokine interloxin-6, and many severely ill people are reported to develop acute respiratory distress syndrome.

A study conducted in the United Kingdom on people infected with the new coronavirus announced that the administration of dexamethasone reduced the mortality rate of patients who required oxygen administration.

However, there was no improvement in mildly ill patients who did not require supplemental oxygen.

It is a powerful drug used for many immune system disorders

The active ingredient, dexamethasone, is known for its long duration of action among synthetic adrenocortical hormones. It is also characterized by a stronger anti-inflammatory effect than glucocorticoids, which are anti-inflammatory hormones that are naturally present in the body. It has been applied to a wide range of immune system diseases as it suppresses the inflammatory response regardless of the cause of inflammation.

It reduces the production of substances that cause inflammation and suppresses excessive inflammatory reactions.

Dexamethasone is a synthetic corticosteroid that mimics the actions of natural glucocorticoids. This medicine exhibits anti-inflammatory effects such as inhibiting the synthesis of substances that cause inflammation and preventing the migration of inflammatory cells to other sites.

When dexamethasone binds to cytoplasmic or nuclear receptors, anti-inflammatory proteins such as lipocortin-1 are synthesized and inhibit phospholipase A2. Inhibition of phospholipase A2 reduces the production of substances that cause inflammation, such as prostaglandins and thromboxanes.

How to take Demisone 0.5mg

1 Dose

1 to 16 tablets (0.5 to 8mg as dexamethasone)

Number of doses per day

1 to 4 times

Side Effects of Demisone 0.5mg

Major side effects

• frustration
• hyperglycemia
• high blood pressure
• gastrointestinal upset
• insomnia
• weight gain
• Increased intraocular pressure (glaucoma)
• Infection
• osteoporosis
• Dyslipidemia
• full moon face
• obesity
• Cataract
• Acne

In particular, infection, osteoporosis, dyslipidemia, full moon face, obesity, and cataract are more likely to occur with long-term use. Long-term use also reduces adrenal function. Sudden discontinuation of the drug when the adrenal glands are underperforming can lead to a shortage of steroid hormones, leading to withdrawal symptoms such as malaise, nausea, and headache.

Rare side effects

• induced infection
• hatred of infectious diseases
• Secondary adrenocortical insufficiency
• Diabetes
• peptic ulcer
• gastrointestinal perforation
• pancreatitis
• psychosis
• depression
• convulsions
• osteoporosis
• Aseptic necrosis of femoral head and humerus
• myopathy
• Vertebral compression fracture
• Pathologic fracture of long bone
• Glaucoma
• posterior capsule cataract
• thromboembolism

Serious side effects such as induced infection, exacerbation of infection, secondary adrenocortical insufficiency, diabetes mellitus, and peptic ulcer may also occur (all unknown frequency).

Pay attention to your physical condition while taking this medicine, and if you feel any abnormality, stop taking this medicine and consult a doctor.

Precautions for Demisone 0.5mg

Careful administration

The following people should be careful when taking this medicine.

• People with infections (excluding patients with infections and systemic mycoses for which there are no effective antibacterial agents)
• people with diabetes
• people with osteoporosis
• people with hypothyroidism
• person with fatty liver
• person with fat embolism
• person with myasthenia gravis
• A person who is a hepatitis B virus carrier
• People with renal or hepatic dysfunction
• pregnant or breastfeeding
• children, elderly

Persons who should not take

The following people cannot use this medicine.

• Persons with a history of hypersensitivity to the ingredients of this drug
• Persons with infections or systemic mycoses for which there are no effective antibacterial agents
• people with peptic ulcer
• psychotic person
• people with tuberculosis disease
• People with herpes simplex keratitis
• person with posterior capsule cataract
• person with glaucoma
• people with hypertension
• people with electrolyte disorders
• people with thrombosis
• People whose surgical wounds on internal organs have not healed
• A person who has had an acute myocardial infarction
• People with poorly controlled diabetes

Contraindications for co-administration

Avoid using this medicine in combination with the following medicines.

• Disulfiram (Knockbin)
• Cyanamide (Cyanamide)
• Desmopressin Acetate Hydrate (Minilin Melt)
• Rilpivirine Hydrochloride (Edurant)
• rilpivirine hydrochloride/tenofovir alafenamide fumarate/emtricitabine (Odefcy)
• rilpivirine hydrochloride/tenofovir disoproxil fumarate/emtricitabine (Complera)
• Rilpivirine Hydrochloride/Dolutegravir Sodium (Jalca)
• Daclatasvir hydrochloride (Daklinza)
• Asunaprevir (Sunvepra)
• Daclatasvir Hydrochloride/Asunaprevir/Beclabuvir Hydrochloride (Dimency)

How to store Demisone 0.5mg

• Store at room temperature, avoiding direct sunlight and high temperature and humidity.
  It does not need to be refrigerated and should be kept at room temperature away from direct sunlight, heat and humidity.
• Keep out of reach of children.
  Avoid the possibility of taking it by mistake.

Other Allergy Relief Products :

• Ebasil 10mg Tablet
• Formonide 200 Capsule
• Incid-L 10mg Tablet
• Montair 10mg Tablet

Shipping/packaging

Country of origin
India

Estimated time of arrival
7-14 days

• Delivery may be delayed due to weather in the country of origin or holidays of vendors in the country of origin.
• Delivery may be delayed in some areas such as remote islands and remote islands.